Decreased Ghrelin and Weight Loss after Billroth and Gastrectomy

gastrectomy with Billroth reconstruction

Weight loss occurred in all study subjects
Body mass index, waist circumference and body fat significantly decreased 1 year after subtotal gastrectomy.

The plasma ghrelin concentration decreased significantly

decreased ghrelin might contribute directly to reduced body fat after Gastrectomy

Amplify’d from www.ncbi.nlm.nih.gov

Eur J Clin Nutr. 2010 Aug;64(8):826-31. Epub 2010 May 19.

Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight.

Jeon TY, Lee S, Kim HH, Kim YJ, Lee JG, Jeong DW, Kim YJ.

Department of Surgery, Pusan National University Hospital, Busan, South Korea.

Abstract

BACKGROUND/OBJECTIVES: No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)(3-36) levels.

SUBJECTS/METHODS: Eighteen patients with early gastric cancer underwent subtotal gastrectomy with Billroth I reconstruction. We assessed appetite, food intake, body composition, and ghrelin and PYY(3-36) levels preoperatively and 1 year after surgery.

RESULTS: There were no significant difference in the preoperative daily food intake and 1 year after subtotal gastrectomy. Weight loss occurred in all study subjects; 11.7% (n=2), 55.5% (n=10) and 33.3% (n=6) of the patients lost <5%, 5-10% and >10% of their preoperative body weight, respectively. Body mass index, waist circumference and body fat significantly decreased 1 year after subtotal gastrectomy. There were no significant differences in the appetite visual analogue scale preoperatively and 1 year after subtotal gastrectomy. The plasma ghrelin concentration decreased significantly (P=0.006), whereas PYY(3-36) did not show a significant change 1 year after subtotal gastrectomy.

CONCLUSIONS: Ghrelin levels and body fat decreased significantly, whereas PYY(3-36) levels as well as appetite and food intake did not change significantly 1 year after subtotal gastrectomy with normal body weight. These findings suggest that decreased ghrelin might contribute directly to reduced body fat.

Read more at www.ncbi.nlm.nih.gov

 

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