Gluten-free diet produced rapid in celiac disease-antibodies

Gluten-free diet treatment produced rapid and significant qualitative and quantitative changes in celiac disease-related antibodies

Amplify’d from www.ncbi.nlm.nih.gov

Dig Liver Dis. 2010 May;42(5):352-8. Epub 2009 Aug 12.

Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment.

Sugai E, Nachman F, Váquez H, González A, Andrenacci P, Czech A, Niveloni S, Mazure R, Smecuol E, Cabanne A, Mauriño E, Bai JC.

Small Bowel Section, Department of Medicine, Dr. C. Bonorino Udaondo Gastroenterology Hospital, Buenos Aires, Argentina.

Abstract

BACKGROUND: The usefulness of celiac disease-related serology in monitoring patients on a gluten-free diet has been debated.

AIM: To describe serologic changes over time and assess whether serology tests can predict compliance with the gluten-free diet.

METHODS: Sera obtained at baseline and every 3 months thereafter for 1 year in 82 adult celiac disease patients were assayed for: (1) IgA antigliadin, (2) IgA anti-tissue transglutaminase, (3) IgA endomysial, (4) IgA, and (5) IgG anti-deamidated gliadin peptides, (6) dual detection of IgA and IgG anti-deamidated gliadin peptides, (7) a single assay for IgA and IgG of both anti-deamidated gliadin peptide and anti-tissue transglutaminase, and (8) IgA antiactin antibodies.

RESULTS: At 3 months after diagnosis, most antibody assays significant decrease in mean concentrations (p<0.0001) and the percentage of positive samples (p<0.0001) with further improvement in subsequent determinations. Strictly adherents had significantly lower concentrations of antibodies (p<0.01 to p<0.00001) and smaller proportion of positive samples for IgA endomysial, IgA antiactin antibodies and IgA antigliadin (15.6%, 17.4% and 23.9%, respectively) than partially compliant. At 1 year, IgA endomysial (p<0.02), IgA antiactin antibodies (p<0.05) and anti-tissue transglutaminase (p<0.02) predicted the degree of compliance.

CONCLUSIONS: Gluten-free diet treatment produced rapid and significant qualitative and quantitative changes in celiac disease-related antibodies which may be useful for monitoring dietary compliance.

Read more at www.ncbi.nlm.nih.gov

 

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