Effects of Gastric Bypass Surgery on Ghrelin

Effects of Gastric Bypass Surgery on Ghrelin

Paradoxically “Fasting serum ghrelin levels were ** lower ** in obese subjects compared with controls “

Despite a 10% weight loss, fasting serum ghrelin levels were paradoxically further decreased in obese subjects 6 weeks after RYGBP

Amplify’d from www.nature.com

Obesity Research (2004) 12, 1108–1116; doi: 10.1038/oby.2004.139

Short-Term Effects of Gastric Bypass Surgery on Circulating Ghrelin Levels**

Rosa Morínigo
  1. *Obesity Unit, Clínic Universitari, Barcelona, Spain
  1. Hormonal Unit, Hospital Clínic Universitari, Barcelona, Spain

Abstract

Objective: To prospectively evaluate the short-term effects of Roux-en-Y gastric bypass (RYGBP) on ghrelin secretion and its relevance on food intake and body weight changes.

Results: Fasting serum ghrelin levels were lower in obese subjects compared with controls (p < 0.05). Meal ingestion significantly suppressed ghrelin concentration in controls (p < 0.05) and obese subjects (p < 0.05), albeit to a lesser degree in the latter group (p < 0.05). Despite a 10.3 plusminus 1.5% weight loss, fasting serum ghrelin levels were paradoxically further decreased in obese subjects 6 weeks after RYGBP (p < 0.05). Moreover, at this time-point, food intake did not elicit a significant ghrelin suppression. The changes in ghrelin secretion after RYGBP correlated with changes in insulin sensitivity (p < 0.05) and caloric intake (p < 0.05).

Discussion: This study showed that the adaptive response of ghrelin to body weight loss was already impaired 6 weeks after RYGBP. Our study provides circumstantial evidence for the potential role of ghrelin in the negative energy balance in RYGBP-operated patients.

Read more at www.nature.com

 

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