Soy is Good for your Bones
Soy Isoflavones appear to stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption.
Evidence of a beneficial effect of isoflavones on bone health in peri- and postmenopausal women when high-isoflavone soy protein is incorporated in the diet.
Conclusions Most of the studies suggest a positive relationship between isoflavones and bone health.
Climacteric. 2010 Nov 17. [Epub ahead of print]
Isoflavones: effects on bone health.
Institut Clinic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, University of Barcelona, and Hospital Clinic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona.
Background There are many effects described, both experimental and clinical, that assess the relationship between isoflavones and bone. It has been hypothesized that isoflavones may have a positive effect on bone health. Objective To review the effects of isoflavones on biochemical markers of bone remodeling, bone density and bone quality, and finally on fracture incidence. Methods A systematic review was carried out of in vitro, animal, and human studies involving isoflavones and bone health. An electronic search was made, based on Internet search engines, MEDLINE (1966-June 2010) and the Cochrane Controlled Clinical Trials Register. This search was further supplemented by a hand-search of reference lists of selected review papers. Results After crossing-cleaning the reference lists, 737 studies dealing with isoflavones and bone were identified. Of these, 36 were considered selectable. From in vitro and animal studies, isoflavones appear to stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption. Reviewed data show evidence of a beneficial effect of isoflavones on bone health in peri- and postmenopausal women when high-isoflavone soy protein is incorporated in the diet. Inconsistencies observed among data from different studies are related to differences in study design, the variety of soy sources of isoflavones, time of analysis, and the variability in the bioavailability and metabolism of isoflavones. Conclusions Most of the studies suggested a positive relationship between isoflavones and bone health.