Zinc; An Antacid? Who Knew?

Zinc; An Antacid? Who Knew?

Yale University Researchers show that * ZINC * offers a novel rapid and prolonged therapy to Blocks Gastric Acid in human and rat models.

Amplify’d from www.ncbi.nlm.nih.gov

Am J Gastroenterol. 2011 Jan;106(1):62-70. Epub 2010 Aug 24.

Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion.

Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, Geibel JP.

Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA. pkirchhoff@hotmail.com

Abstract

OBJECTIVES: The overproduction of acid and the associated illnesses linked to hypersecretion have a lifetime prevalence of 25-35% in the United States. Although a variety of pharmaceutical agents have been used to reduce the production of acid, alarming new evidence questions the long-term efficacy and safety of the agents. These issues coupled with the delayed onset of action and the return of symptoms in over 60% of the patients is less than satisfactory. The purpose of this study was to determine whether administration of a zinc salt could lead to a rapid and sustained increase in gastric pH in both animals and in humans and provide a new rapid acid suppression therapy.

METHODS: Intracellular pH was measured with 2′,7′-bis-(2-carboxyethyl)-5-and-6-carboxy-fluorescein in both human and rat gastric glands following an acid load±a secretagogue. In a separate series of studies, whole stomach acid secretion was monitored in rats. A final study used healthy human volunteers while monitoring with a gastric pH measurement received placebo, zinc salt, or a zinc salt and proton pump inhibitor (PPI).

RESULTS: We demonstrate that exposure to ZnCl(2) immediately abolished secretagogue-induced acid secretion in isolated human and rat gastric glands, and in intact rat stomachs. Chronic low-dose zinc exposure effectively inhibited acid secretion in whole stomachs and isolated glands. In a randomized cross-over study in 12 volunteers, exposure to a single dose of ZnCl(2) raised intragastric pH for over 3  h, including a fast onset of effect.

CONCLUSIONS: Our findings demonstrate that zinc offers a novel rapid and prolonged therapy to inhibit gastric acid secretion in human and rat models.

Read more at www.ncbi.nlm.nih.gov

 

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