Vitamin E may * Increase * Mortality

I. ISSUE
Authors of a recently published meta-analysis demonstrated that high-dose vitamin E may increase all-cause mortality.1 As a result of their findings, the authors recommend avoidance of high-dose vitamin E.

IV.

VA MEDSAFE RECOMMENDATIONS
Since there is an abundance of data suggesting that
* supplementation with vitamin E has no apparent benefit *
in preventing or reducing cardiovascular events but there are some data
suggesting an
* increased risk in all-cause mortality,*
* high-dose (>400 IU) vitamin E should be removed from the VA National Formulary.

VA MedSafe will request the MAP and VISN formulary leaders to
* remove high-dose vitamin E supplements from the VA National Formulary.*

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