Antiobesity effect of trans-10,cis-12-co

Antiobesity effect of trans-10,cis-12-conju… [J Appl Microbiol. 2007] – PubMed – NCBI http://ow.ly/9nMbC

Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice.
Lee K, Paek K, Lee HY, Park JH, Lee Y.
Source
Culture Collection of Antimicrobial Resistant Microbes, Department of Biology, Seoul Women’s University, Seoul, Korea.
Abstract
AIMS:
To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice.
METHODS AND RESULTS:
Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans-10,cis-12-conjugated linoleic acid (6.4 microg ml(-1)), and the crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 microg mg(-1) protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice (P<0.01).
CONCLUSIONS:
trans-10,cis-12-CLA-producing Lact. plantarum PL62 can exert the same antiobesity activity as trans-10,cis-12-CLA in mice.
SIGNIFICANCE AND IMPACT OF THE STUDY:
trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity.

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