The effects of metformin or orlistat o..

The effects of metformin or orlistat o… [J Assist Reprod Genet. 2011] – PubMed – NCBI http://ow.ly/9nILt
J Assist Reprod Genet. 2011 Jul;28(7):591-6. Epub 2011 Apr 12.
The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study.
Ghandi S, Aflatoonian A, Tabibnejad N, Moghaddam MH.
Source
Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran. sedighe_ghandi@yahoo.com
Abstract
PURPOSE:
Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome.
METHODS:
A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects’ ovulatory status was assessed after 3 months.
RESULTS:
There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH.
CONCLUSIONS:
Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.

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