Nature Clinical Practice Endocrinology & Metabolism (2007) 3, 574-583
Received 26 June 2006 | Accepted 13 April 2007
Surgical treatment of obesity
John G Kral* and Erik Näslund About the authors
Correspondence *Department of Surgery, State University of New York Downstate Medical Center, Box 40, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA
Obesity is very prevalent. Most treatments fail owing to hard-wired survival mechanisms, linking stress and appetite, which have become grossly maladaptive in the industrial era. Antiobesity (bariatric) surgery is a seemingly drastic, efficacious therapy for this serious disease of energy surfeit. Technical progress during the last two decades has greatly improved its safety. The surgical principles of gastric restriction and/or gastrointestinal diversion have remained largely unchanged over 40 years, although mechanisms of action have been elucidated concomitant with advances in knowledge of the molecular biology of energy balance and appetite regulation. Results of bariatric surgery in large case-series followed for at least 10 years consistently demonstrate amelioration of components of the insulin-resistance metabolic syndrome and other comorbidities, significantly improving quality of life. Furthermore, bariatric surgery has convincingly been demonstrated to reduce mortality compared with nonoperative methods. This surgery requires substantial preoperative and postoperative evaluation, teaching, and monitoring to optimize outcomes. In the absence of effective societal changes to restore a healthy energy balance, bariatric surgery is an important tool for treating a very serious disease.
We searched MEDLINE and PubMed for articles published between 2000 and 2006, using the terms “obesity”, “surgery”, “appetite” and “weight loss”. We excluded reports with lengths of observation under 5 years, lacking data on follow-up rates, type of practice, and information on source of follow-up data. We favored articles in journals with explicit policies governing conflicts-of-interest, and stringent peer-review processes, although we had to make exceptions when such sources were lacking. We systematically chose to present data from larger replicated studies with longer periods of observation when possible, although we cite reviews and meta-analyses with less-stringent criteria than ours.
Medscape Continuing Medical Education online
Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit. Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide CME for physicians. Medscape, LLC designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. To receive credit, please go tohttp://www.medscape.com/cme/ncp and complete the post-test.
Upon completion of this activity, participants should be able to:
- Identify the currently available techniques associated with different types of bariatric surgery.
- Describe the likely mechanisms of action of bariatric surgery.
- Describe the weight-loss benefits associated with bariatric surgery for obese patients.
- Identify the advantages of gastrointestinal diversion compared with the restrictive method of bariatric surgery.
- Compare the complication rates associated with open vs laparoscopic approaches in bariatric surgery.
The exponential increase in obesity worldwide has brought into sharp focus the lack of effective methods for treating or preventing the disease. As the prevalence and severity of obesity have been rising, so has the acceptance of increasingly aggressive remedies. It is in this context that the use of antiobesity (bariatric) surgery has grown.1 During 2006 there were 386 English-language publications on “bariatric surgery in humans” (excluding plastic surgery) compared with an average of approximately 31 yearly articles since recording started in 1969. Here we describe the generic types of operations, the mechanisms for weight loss, evolving indications for surgery, outcomes, and aspects of patient selection.
All primary bariatric operations should preferably be performed laparoscopically. Severely obese patients are particularly well served by minimally invasive approaches, which avoid the tissue trauma of large transabdominal incisions in open surgery. Notably, newer, even less invasive, endoscopic surgical methods, based on techniques for treating gastroesophageal reflux,2, 3 are currently being evaluated for treating obesity.
PURELY RESTRICTIVE PROCEDURES
Purely gastric-restrictive operations, such as adjustable gastric banding (Figure 1A) and vertical banded gastroplasty, cause weight loss by limiting the capacity of the stomach to accommodate food and by slowing the flow of ingested nutrients.
Figure 1 Different common techniques of bariatric surgery
(A) Adjustable gastric banding. An inflatable silicone band around the upper stomach partitions it into a 30-ml proximal pouch and a large, distal remnant, connected through a narrow, nondistensible adjustable constriction. (B) Gastric bypass divides the stomach into a small, proximal pouch measuring 30 ml and a separate, large, distal defunctionalized remnant. The upper pouch is joined to the jejunum through a narrow distensible gastrojejunal anastomosis. The proximal divided jejunum is reattached to the jejunum 75–150 cm below the gastrojejunal anastomosis creating a Roux-en-Y limb. (C) Biliopancreatic diversion, with or without a pylorus-sparing ‘duodenal switch’ causes malabsorption as pancreatic and biliary secretions are diverted to the distal small intestine approximately 50 cm from the ileocecal valve. Absorption is thus limited to the distal ileum. A ‘sleeve’ gastrectomy is depicted.
GASTRIC RESTRICTION COMBINED WITH DIVERSION
Gastric bypass reduces the stomach to approximately 5% of its normal volume, and ingested food bypasses approximately 95% of the stomach, the entire duodenum, and 20 cm of the proximal jejunum (Figure 1B). Initially (for the first 6–18 months), the operation relies on gastric restriction, much as does banding.
DIVERSIONARY MALABSORPTIVE PROCEDURES
Malabsorptive procedures bypass or resect the stomach and also bypass long segments of small intestine to reduce the area of mucosa available for nutrient absorption. Biliopancreatic diversion, with or without a pylorus-sparing ‘duodenal switch’, (Figure 1C) promotes selective malabsorption of fat;4 weight loss is effective, but this procedure causes more complications than gastric bypass, such as protein malnutrition, diarrhea, and deficiencies of various vitamins.5
REGULATORY METABOLIC OPERATIONS
Duodenal–jejunal bypass6 and ileal interposition7 are investigational operations, as is truncal vagotomy,8, 9 all with minimal malabsorptive yet significant metabolic effects mediated via neuroregulatory brain–gut peptides. These peptides employ mechanisms believed to cause weight loss through appetitive and metabolic effects present in diversionary operations such as gastric bypass.
MECHANISMS FOR WEIGHT LOSS AFTER BARIATRIC SURGERY
Purely gastric-restrictive procedures cause gastric and/or esophageal distension, eliciting early satiety, nausea and discomfort or even vomiting when pouch capacity is exceeded.10 Esophageal distension activates afferent nerves stimulated by mechanoreceptors and neuropeptides such as Substance P.11, 12Positron emission tomography studies of esophageal distension have identified brain loci in proximity to those associated with appetitive signaling13, 14 and with visceral pain;15 therefore, esophageal signals might participate in regulating (inhibiting) food intake via satiety and/or nimiety signals. Distension of the cardia or the upper stomach also increases activity in the areas involved in appetite regulation.16
After adjustable gastric banding, weight-stable patients with optimal band tightening experience greater post-prandial satiety than those with looser bands.17 Interestingly, patients with optimal adjustment experienced less hunger after an overnight fast, implying that the band might affect satiety through unknown mechanisms perhaps resulting from activation of mechanoreceptors under the band.17
For the first 12–24 months after gastric bypass, the restrictive component decreases as pouch and stoma stretch.18 Thereafter, mechanisms emanating from the diversionary component of gastric bypass prevent weight regain: the pyloric ‘meter’ or ‘brake’ is absent and rapid transit via the gastrojejunostomy is allowed. Maldigestion can also result from the absence of acid and pepsin and the grinding–mixing forces of the stomach. The unphysiological presence of undigested food and liquids rapidly ‘dumped’ into the small bowel causes nimiety via mechanoreceptors and possibly satiety via chemoreceptors.19
Gastric bypass causes profound changes in plasma gut peptide levels. Ghrelin, secreted mainly from the stomach, has been shown to stimulate food intake.20A majority of studies has shown a decrease in plasma ghrelin levels after gastric bypass,21 which is consistent with bypass of the stomach and a rapid stimulation of the small intestine. Peptide YY decreased food intake in obese humans when it was given in a truncated formulation (peptide YY3–36);22 this finding has renewed interest in studying peptide YY. Glucagon-like peptide 1 (GLP-1) also decreases food intake and appetite in obese subjects, as well as stimulating insulin release and inhibiting glucagon secretion.23 This may be one mechanism whereby such methods as duodenal switch and ileal interposition affect glucose disposal and energy balance.
Both peptide YY24 and GLP-125 are released from cells in the distal gut, and levels increase postprandially after gastric bypass, consistent with the rapid stimulation of the lower gut. These increases in appetitive gut peptides may decrease food intake and contribute to the weight loss after gastric bypass.26Interestingly, biliopancreatic diversion exhibits increased levels of ghrelin27whereas GLP-1 is increased more after biliopancreatic diversion than after gastric bypass. This finding might explain why biliopancreatic diversion tends to ameliorate non-insulin-dependent diabetes mellitus more than does gastric bypass.28
New data suggest that ghrelin might influence hedonic feeding. Ghrelin receptors are found in the ventral tegmental area, thought to be a node in the mesolimbic reward pathway with dopaminergic projections to various areas of the brain. Indeed, injection of ghrelin into the ventral tegmental area increases food intake in rats.29 Furthermore, high central leptin concentrations downregulate hypothalamic leptin receptors and impair leptin signaling;30 this downregulation modulates the interaction between leptin and other regulators of appetite (e.g. ghrelin) in the obese state. Decreases in both leptin and ghrelin concentrations after gastric bypass might sensitize leptin pathways and reduce the reward of hedonic eating.
Cholecystokinin, a foregut peptide identified in the vagus nerve, and GLP-1 given in combination did not exhibit additive effects on appetite in humans,31 in contrast to peptide YY3–36 and GLP-1.32 Most current diversionary operations reduce and/or exclude the stomach and pylorus, the site of cholecystokinin and other receptors. Some exclude varying lengths and segments of small bowel, creating ‘short-cuts’ for unabsorbed nutrients, which, therefore, overstimulate or understimulate the duodenum, jejunum or terminal ileum, each with its own complement of peptides (Figure 2).
Figure 2 Topography of putative appetitive signals affected by obesity operations, exemplified here by gastric bypass
(A) Gastric restriction causes distension of the upper stomach, esophagus, and cardia. This activates afferent mechanoreceptors and neuropeptides (e.g. substance P) that seem to inhibit food intake via satiety and/or nimiety signals; similar signals might originate from the small bowel after gastric bypass (not shown). (B) Gastric bypass seems to decrease ghrelin levels owing to more rapid exposure of small intestine to nutrients. Ghrelin (from the stomach) increases food intake, acting both via the vagal nerve (the NTS) and via the ARC of the hypothalamus; (C) there, neurons that either contain POMC or contain NPY plus AgRP signal to second-order neurons in the PVN (another area of the hypothalamus involved in feeding) via, for example, MC4R. In the ventral tegmental area of the midbrain, effects of gastric bypass on ghrelin and leptin levels might interact to reduce hedonic reward (not shown). Gastric bypass can also exclude foregut-derived peptides such as cholecystokinin, which acts via the vagus nerve (not shown). (D) Gastric bypass increases levels of PYY and GLP-1 (from distal gut), which suppress food intake. Like ghrelin, PYY and leptin can act within the ARC and NTS; the effects of ghrelin in stimulating neurons containing NPY plus AgRP often oppose those of leptin. GLP-1 also stimulates insulin and inhibits glucagon secretion (not shown). Abbreviations: +, stimulation; -, inhibition; AgRP, Agouti-related protein; ARC, arcuate nucleus; GLP-1, glucagon-like peptide 1; MC4R, melanocortin 4 receptor; NPY, neuropeptide Y; NTS, nucleus tractus solitarius; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus; PYY, peptide YY.
INDICATIONS FOR SURGERY
Indications for surgery evolved in the United States during the 1980s and were formulated in the 1991 National Institutes of Health Consensus Development Conference on gastrointestinal surgery for severe obesity.33 The weight criterion for undergoing surgery, expressed in terms of BMI, was broadened from a BMI of at least 40 kg/m2 to include a BMI of at least 35 kg/m2 in the presence of manifest comorbidity. Individuals with a BMI of at least 35 kg/m2sustained for more than 1 year exhibit comorbidity if thoroughly evaluated. Dyslipidemia, impaired glucose metabolism, fatty liver, and poor quality of life appear very early in the natural history of obesity; these conditions are increasingly appearing in children.
Age criteria for candidacy for bariatric surgery have widened in parallel with the growing prevalence of severe obesity, the most rapidly increasing class of obesity. Longer duration of exposure to obesity decreases the likelihood of sustainable remission or cure,34 arguing for early intervention. “Early”, in this context, may be defined as shortly after attaining a critical BMI, in analogy with early treatment of diabetes.35 With the availability of laparoscopic approaches, older patients are increasingly having bariatric surgery. Just as age criteria have widened during recent years, so have the weight criteria. Several studies have used lower BMI limits (BMI 30–35 kg/m2),36, 37 a trend that is growing.
Indications for reoperative bariatric surgery are not defined, and criteria for choice of secondary or ‘rescue’ procedures have not been developed. In our opinion ‘failure’ is best defined as recurrence of comorbidity accompanying postoperative weight gain. This has been reported to occur in about 25% of patients, depending on procedure, although data on reoperation rates are frequently absent. It is absolutely essential that the team taking care of a patient with weight regain ascertain probable causes, rather than simply ascribing it to surgical–technical problems.
BENEFITS OF SURGERY
Weight loss per se is likely to be the least important measure of bariatric surgical outcomes, although it is highly correlated with recognized risk factors and with patient satisfaction. Weight loss is conventionally expressed as percent excess weight loss (%EWL). “Excess” refers to the weight that exceeds actuarial standards of weight adjusted for height (‘desirable’ or ‘ideal’ weight) corresponding to minimal mortality. In a recent meta-analysis, mean EWL (and 95% CI) after biliopancreatic diversion was 70.1% (66.3–75.9%), gastric bypass 61.6% (56.7–66.5%), vertical banded gastroplasty 68.2% (61.5–74.8%) and adjustable gastric banding 47.5% (40.7–54.2%).38 There are very few long-term (>10 year) studies of laparoscopic adjustable gastric banding, and none from the United States because the band was not approved there until 2001. A recent comparison of patients with open vertical banded gastroplasty versus laparoscopic adjustable gastric banding after 10 years (follow-up, 90%) demonstrated EWL of 59% for vertical banded gastroplasty and 62% for adjustable gastric banding.39
Weight loss after adjustable gastric banding has generally been greater in Europe and Australia than in the United States, with fewer operative complications,40, 41, 42 although some later studies from the US have shown improved results.43 These differences might result from eating behavior and marketing of food, as well as the severity of obesity, in the different populations.
Reducing mortality is the most important goal of bariatric surgery. In 2006, the Swedish Obese Subjects study,44 the first prospective controlled study designed specifically to assess mortality, reported significantly lower mortality over 10 years in operated patients than in those treated conventionally.45Other studies, using different types of databases, for example national death registries, case–control series and public health agencies, also suggest that mortality is reduced after surgery.46, 47, 48, 49, 50 In Washington State, mortality 15 years after bariatric surgery was 11.3% compared with 16.3% in nonoperated obese subjects.46 A common finding in all these studies is a relatively low perioperative mortality rate. Surgical method (e.g. restrictive in the Swedish Obese Subjects study, and vertical banded gastroplasty in Iowa49versus gastric bypass in Washington State46) and approach (open or laparoscopic) are important when evaluating these data, considering that substantial advances have been made during the last 10 years.
Most obesity comorbidity is ameliorated postoperatively depending on the type of surgery performed.51 Purely gastric-restrictive procedures do not have the durability of comorbidity reduction seen after diversionary operations.34, 52, 53As an example, dyslipidemia is best corrected after biliopancreatic diversion, followed in effectiveness by gastric bypass and adjustable gastric banding.
In the Swedish Obese Subjects study, the incidence of hypertriglyceridemia was reduced from 27% to 17% after 10 years.44 The effect of bariatric surgery on hypertension is complex. Blood pressure is often lower up to 5 years, but in some series hypertension returns after 10 years, probably from weight regain after restrictive operations.44 Non-insulin-dependent diabetes mellitus responds dramatically. In the Swedish Obese Subjects study the incidence of non-insulin-dependent diabetes mellitus was reduced from 24% to 7% at 10-year follow-up in the control group compared with the surgical group.44 Other series demonstrate improvements of up to 85% among patients with non-insulin-dependent diabetes mellitus.38, 50, 51 Table 1 summarizes changes in four major comorbidities over time according to type of operation.38
The rapid increase in childhood obesity demonstrates the importance of the intrauterine environment as a precursor of offspring obesity. Pregnancies in which the mother is obese are hazardous for mother, fetus and child, increasing the prevalence of childhood, and ultimately adult, obesity. Several studies show that prior bariatric surgery ameliorates gestation and delivery and fetal and neonatal health (reviewed by Kral54). A recent study of 113 offspring born after maternal bariatric surgery who were followed for 2–18 years revealed a reduction of obesity to local population standards.55
COMPLICATIONS AND SIDE-EFFECTS
Severe complications have decreased over time; deaths generally occur in less than 1% of patients. The Swedish Obese Subjects study reported 5 deaths in 2,000 patients, corresponding to a mortality rate of 0.2%;44 however, single series and population studies have reported significantly higher mortality rates approaching 2%56, 57, 58 with the highest figures pertaining to complex procedures.
Low perioperative mortality rates affect the interpretation of the role of weight reduction per se on mortality, now demonstrated to be reduced after bariatric surgery.47, 48, 49, 50 Operative mortality is strongly related to surgical volume59and has decreased dramatically with the wide adoption of laparoscopic procedures during the last 6 years. An excellent systematic review comparing short-term mortality among 5,780 patients with laparoscopic adjustable gastric banding (0.05%), 2,858 vertical banded gastroplasty (0.31%) and 9,258 gastric bypass (0.50%) patients demonstrated significantly lower mortality rates with laparoscopic adjustable gastric banding. Vertical banded gastroplasty and gastric bypass groups were not, however, analyzed according to approach (open versus laparoscopic), and percentage of follow-up was not tabulated.60The most common causes of death are pulmonary embolism, (unrecognized) intra-abdominal leaks and myocardial infarction, although the incidence of fatal myocardial infarction is lower after surgical than medical treatment of obesity.56
Some complications are procedure-specific: adjustable gastric banding does not entail entering the gastrointestinal tract and does not affect bowel function. Band erosion can cause pain and ulcers. Pouch enlargement and band slippage can result in acid reflux, and slippage can also contribute to vomiting. Acid reflux is uncommon after gastric bypass because most of the stomach and acid-producing cells are excluded, but it can occur after biliopancreatic diversion, owing to a larger proximal stomach and diversion of bile.
Similarly, surgical approach (open versus laparoscopic) affects the types of complications. A recent review of gastric bypass61 found statistically significant differences in numerous complications, particularly wound problems in 6.6% of open procedures compared with 3.0% in laparoscopic cases. Incisional hernias are more common after open surgery, whereas other complications are more common after laparoscopic surgery: small-bowel obstruction (3.1% versus 2.1%), anastomotic stenosis (4.7% versus 0.7%) and gastrointestinal bleeding (1.9% versus 0.6%). There were no differences in the number of leaks (1.2%), pulmonary emboli (<1%) or pneumonia (0.1–0.3%). The cause of the higher incidence of small-bowel obstruction early after laparoscopic surgery is probably internal hernia.
The most important long-term adverse effects are deficiencies of vitamins and minerals, especially after diversionary malabsorptive operations. Gastric-restrictive operations have mostly caused iron deficiency in menstruating women, owing to reduced intake of meat, and excessive vomiting can cause thiamine deficiency resulting in neuropathy. Gastric bypass and biliopancreatic diversion are associated with deficiencies of Vitamin B12,62 folate, calcium and vitamin D.63, 64 In the long term, peripheral neuropathy can occur (up to 16% in some series). Patients are urged to have blood nutrient levels monitored and to take oral vitamin supplementation. The varying efficacy of oral vitamin B12supplementation is partly related to patient adherence, although some studies have demonstrated decreased uptake after surgery.62 Bone loss tends to occur during the first year after gastric bypass surgery and then stabilizes with unchanged vitamin D levels.64
The most problematic long-term complication of bariatric surgery is poor or inadequate weight loss. Reoperations are more difficult than primary procedures and have higher perioperative complication rates.65 Failed gastric-restrictive procedures are, nevertheless, best handled by conversion to a diversionary operation.66 Long-term failure of diversionary operations requires adjustment of intestinal limb lengths to create more malabsorption, with the risk of creating frank malnutrition. Should this occur, one or more trials of parenteral nutrition support are sufficient to enable non-bypassed intestine to recover its compensatory capacity, in our experience decreasing the risk of recurrent malnutrition.
Handling patients at increased risk, such as those who are very obese or those with severe comorbidities, is a continuing problem.67 The cost-effectiveness of a staged surgical strategy for operative risk-reduction has not been compared with nonoperative methods, such as conventional outpatient diet, exercise, behavior modification, intragastric balloon, intermaxillary fixation (‘jaw wiring’), pharmacotherapy or monitored in-patient calorie control using very low calorie diets. On a cost per unit weight loss per unit time basis, surgical methods are nevertheless superior both over the short and the long term.
In our opinion, older, heavier patients, with more serious comorbidities, might benefit from a laparoscopically placed adjustable gastric band, the simplest, quickest and least complication-prone operation, until medically significant weight loss has occurred. Thereafter, a more complex and durable, diversionary, malabsorptive procedure should be considered in order to increase the likelihood of sustaining the weight loss. Gagner and colleagues suggested using sleeve gastrectomy in a two-staged approach in this setting,68 although any resective operation involves more risk of complications than simple band placement.
COST–BENEFIT ANALYSES IN BARIATRIC SURGERY
As with all therapy, there has been a long-standing interest in cost efficiency analyses for bariatric surgery.69, 70 There are no published cost–benefit comparisons between, for example, adjustable gastric banding and other simple operations, accounting for cost of device and postoperative visits for band adjustment. Careful review of economic, health, quality of life and survival benefits of bariatric surgery would have to be balanced against the costs of side-effects, complications and death, taking into consideration geographic, socio-economic and setting-specific costs that can vary between countries with different accounting practices and methods for delivery of care. Although the Swedish Obese Subjects study might be well suited to perform a cost–benefit analysis (and has, indeed, studied sick leave, disability and medication costs), given the uniformity of delivery of care in the tightly regulated socialized system of a relatively small country with excellent demographic resources, it is difficult to extrapolate the findings to other countries or settings. There are, furthermore, concerns about the relevance of the treatment arm of this study because it is mainly based on an obsolete operation.71
STANDARDS FOR BARIATRIC SURGERY
As with all surgery there is a learning curve, particularly for laparoscopic bariatric surgery. Data suggest that competency requires the performance of 75–100 cases.72 High-volume (>100 cases per year) centers have better results than low-volume centers (<50 cases per year).59 This is true for length of stay, overall complications, costs and mortality rate and is especially true for older patients (>60 years). Owing to great variations in the quality of care in the United States, several initiatives have been taken to define minimal performance parameters for hospitals to qualify for insurance reimbursement. A ‘center of excellence’ designation requires the meeting of standards for volume, equipment, human resources, reporting and complication rates. Equally important as the number of cases performed is the availability of a dedicated, competent team to assess, educate and take care of patients before and after surgery.
There are several different classes of outcomes after bariatric surgery: perioperative and postoperative complications and adverse effects, comorbidity reduction, weight-loss maintenance, improved economy, psychosocial improvement, and objective and subjective quality of life changes. They are interrelated and associated with weight loss, which alone is an inadequate outcome measure. Just as quality of life is multidimensional,73 so is the definition of ‘successful’ outcome,74 making it difficult to identify specific predictors useful for patient selection.75 The largest source of variance in studies of outcome and its predictors is duration of post-treatment observation, including percentage of patients lost to follow-up, sadly neglected in the preponderance of literature on weight loss regardless of method. The majority of publications on bariatric surgery, whether observational or mechanistic, include patients during various phases of weight change, which might explain conflicting data especially during rapid weight loss.
Classic predictors of outcome such as age, weight and sex have been studied with regard to bariatric surgery. One systematic review of age effects demonstrated inconsistent results: six studies found younger patients lost more weight, whereas four did not. Heavier patients lost less weight. Male sex and high age and preoperative weight are risk factors for increased postoperative complications.76 Five postoperative categories associated with poor long-term outcomes of bariatric surgery have been identified: poor patient knowledge; psychosocial maladaptation; anatomic complications; gastrointestinal pathophysiology; and weight-related symptomatology.77 There is considerable interaction and overlap among these categories, but they are equally important to recognize and address in patient selection.78 African-American patients seem to experience less weight loss after bariatric surgery than white patients;79 however, the improvement in comorbidity was similar in one study.80
Eating behavior has been relatively neglected although bariatric surgery to a great extent is ‘behavioral surgery’. Preoperative education about how to eat and what to do if vomiting occurs, as it can, after adjustable gastric banding or early after gastric bypass, is essential.78
Studies on the importance of binge eating disorder (BED) are equivocal. Two retrospective studies suggested that BED is a negative predictor,81, 82 whereas two prospective studies did not demonstrate any relationship between BED and postoperative outcome.83, 84 One retrospective study suggested that biliopancreatic diversion might correct BED.85 Mutations in the melanocortin 4 receptor gene have been implicated in BED,86 although the findings are disputed.87 Outcomes 3 years after adjustable gastric banding in 300 patients nevertheless clearly demonstrated poorer weight loss, less amelioration of comorbidity and more complications in patients who have mutations in their melanocortin 4 receptor than in patients who have BED but no known mutations in the receptor.88 A small subset of patients with polymorphisms who were converted to gastric bypass seemed to have a poorer weight loss than those without.
It is too early to determine an optimal strategy that is based on eating behavior or BED with or without gene abnormalities. Operative treatment is nevertheless more effective than any other method in this context: BED is not a contraindication for bariatric surgery. Heavier patients (BMI >50 kg/m2) have a more serious eating disorder, accounting for variations in published results.
Confusion among surgeons89 and other health-care professionals90 about goal weights pertains to determining ‘sufficient’ or ‘optimal’ weight goals for patients who are, or have been, severely obese. How much weight loss is enough?
Unfortunately, there is a widespread misconception that, after surgery, a BMI of greater than 30 kg/m2 represents an unhealthy body weight in patients who have lost weight—that the inability to bring patients under this arbitrary threshold constitutes failure of surgery. There is sufficient, although sparse, actuarial evidence to conclude that sustained voluntary weight loss is associated with lower morbidity and mortality than the morbidity or mortality of the general population at the same level of BMI.91 Patients with a BMI above 30 kg/m2 and who have lost weight after surgery after previously having had BMIs of at least 35–40 kg/m2 have lower risk of death or disease than those who never lost weight, contrary to the case with ‘failure’ of nonsurgical weight-loss treatment.
In 1988 we introduced the concept of a staged surgical approach based on experience with ‘rescue’ operations after failed gastric-restrictive surgery.92Because of the introduction of the less invasive laparoscopic approaches and development of the adjustable gastric band, in 1991 we proposed the use of a staged approach as a method for patient selection,93 given the high failure rate of gastric restriction and the inability to predict which patients might benefit most from such operations. This approach allows the more complex, complication-prone operations to be reserved for patients with failure of, or unable to tolerate, gastric restriction, and was subsequently embraced by Mason,94 the inventor of gastric bypass and vertical banded gastroplasty, and incorporated into a systematic treatment algorithm for rescuing patients with failure of laparoscopic adjustable banding.95
Although techniques can be developed to outsmart energy-saving genes and polymorphisms, it is not likely that the second law of thermodynamics will be repealed in the foreseeable future. After obesity surgery there is a clear relationship between the magnitude of weight loss and the durability and extent of improvement of comorbidity, modified by the duration of disease exposure before surgery. For now, bariatric surgery has an important role to play and should be provided early in the disease process, when other methods have failed.
- Bariatric surgery is safe; complications are fewer after restrictive procedures but weight loss and comorbidity reduction are greater after diversionary procedures
- Most obesity comorbidity is durably (>10 years) ameliorated after surgery and mortality is less than after nonsurgical care
- After bariatric surgery most patients do not reach ‘normal’ weight; however, the weight loss induced by surgery is sufficient to improve morbidity and mortality
- A dedicated, comprehensive team is needed to assess, educate and manage the patient before and after surgery
Désirée Lie, University of California, Irvine, CA, is the author of and is solely responsible for the content of the learning objectives, questions and answers of the Medscape-accredited continuing medical education activity associated with this article.
- Santry HP et al. (2005) Trends in bariatric surgical procedures. JAMA 294: 1909–1917 | Article | PubMed | ISI | ChemPort |
- Awan AN and Swain CP (2002) Endoscopic vertical band gastroplasty with an endoscopic sewing machine. Gastrointest Endosc 55: 254–256 | Article | PubMed | ISI |
- Mahmood Z et al. (2006) Comparison of transesophageal endoscopic plication (TEP) with laparoscopic Nissen fundoplication (LNF) in the treatment of uncomplicated reflux disease. Am J Gastroenterol 101: 431–436 | Article | PubMed | ISI |
- Tataranni PA et al. (1996) Twenty-four-hour energy and nutrient balance in weight stable postobese patients after biliopancreatic diversion. Nutrition 12: 239–244 | Article | PubMed | ISI | ChemPort |
- Scopinaro N et al. (1998) Biliopancreatic diversion. World J Surg 22: 936–946 | Article | PubMed | ISI | ChemPort |
- Cohen R et al. (2007) Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with BMI 22-34: a report of 2 cases. Surg Obes Relat Dis3: 195–197 | Article | PubMed |
- de Paula AL et al. (2006) Laparoscopic sleeve gastrectomy with ileal interposition (“neuroendocrine brake”)—pilot study of a new operation. Surg Obes Relat Dis 2: 464–467 | PubMed |
- Kral JG (1980) Effects of truncal vagotomy on body weight and hyperinsulinemia in morbid obesity. Am J Clin Nutr 33: 416–419 | PubMed | ISI | ChemPort |
- Boss TJ et al. (2007) Laparoscopic truncal vagotomy for severe obesity: six month experience in 10 patients from a prospective, two-center study [abstract]. Surg Obes Relat Dis 3: 292
- Pappas TN (1992) Physiological satiety implications of gastrointestinal antiobesity surgery. Am J Clin Nutr 55: 571S–572S | PubMed | ChemPort |
- Singaram C et al. (1991) Peptidergic innervation of the human esophageal smooth muscle. Gastroenterology 101: 1256–1263 | PubMed | ISI | ChemPort |
- Neuhuber WL et al. (2006) Innervation of the mammalian esophagus. Adv Anat Embryol Cell Biol 185: 1–73 | PubMed | ISI |
- Aziz Q et al. (1997) Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 113: 50–59 | Article | PubMed | ISI | ChemPort |
- Tataranni PA et al. (1999) Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc Natl Acad Sci USA 96: 4569–4574 | Article | PubMed | ChemPort |
- Yaguez L et al. (2005) Brain response to visceral aversive conditioning: a functional magnetic resonance imaging study. Gastroenterology 128: 1819–1829 | Article | PubMed | ISI |
- Stephan E et al. (2003) Functional neuroimaging of gastric distention. J Gastrointest Surg 7: 740–749 | Article | PubMed | ISI |
- Dixon AF et al. (2005) Laparoscopic adjustable gastric banding induces prolonged satiety: a randomized blind crossover study. J Clin Endocrinol Metab90: 813–819 | Article | PubMed | ISI | ChemPort |
- Linner JG and Drew RL (1992) Reoperative surgery—indications, efficacy and long-term follow-up. Am J Clin Nutr 55: 606S–610S | PubMed | ChemPort |
- Mei N (1985) Intestinal chemosensitivity. Physiol Rev 65: 211–237 | PubMed | ISI | ChemPort |
- Cummings DE et al. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714–1719 | Article | PubMed | ISI | ChemPort |
- Aylwin S (2005) Gastrointestinal surgery and gut hormones. Curr Opin Endocrinol Diabetes 12: 89–98 | Article | ChemPort |
- Batterham RL et al. (2003) Inhibition of food intake in obese subjects by peptide YY3–36. N Engl J Med 349: 941–948 | Article | PubMed | ISI | ChemPort |
- Näslund E et al. (1999) Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men. Int J Obes 23: 304–311 | Article |
- Korner J et al. (2005) Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, PYY and insulin. J Clin Endocrinol Metab 90: 359–365 | Article | PubMed | ISI | ChemPort |
- Borg CM et al. (2006) Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg 93: 210–215 | Article | PubMed | ISI | ChemPort |
- Cummings DE and Overduin J (2007) Gastrointestinal regulation of food intake. J Clin Invest 117: 13–23 | Article | PubMed | ISI | ChemPort |
- Adami GF et al. (2004) Changes in serum ghrelin concentrations following biliopancreatic diversion for obesity. Obes Res 12: 684–687 | PubMed | ISI | ChemPort |
- Greenway SE et al. (2002) Effects of obesity surgery on non-insulin-dependent diabetes mellitus. Arch Surg 137: 1109–1117 | Article | PubMed | ISI |
- Naleid AM et al. (2005) Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens.Peptides 26: 2274–2279 | Article | PubMed | ISI | ChemPort |
- Zhang Y and Scarpace PJ (2006) The role of leptin resistance and obesity.Physiol Behav 88: 249–256 | Article | PubMed | ISI | ChemPort |
- Brennan IM et al. (2005) Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake and antropyloroduodenal motility in healthy men. Am J Physiol 288: R1477–R1485 | ISI | ChemPort |
- Neary NM et al. (2005) Peptide YY3–36 and glucagon-like peptide-17–36 inhibit food intake additively. Endocrinology 146: 5120–5127 | Article | PubMed | ISI | ChemPort |
- National Institutes of Health Consensus Development Conference (1992)Gastrointestinal surgery for severe obesity. Am J Clin Nutr 55 (Suppl): 615s–619s
- Pories WJ et al. (1995) Who would have thought it? An operation proves to be the most effective therapy for adult onset diabetes mellitus. Ann Surg222: 339–350 | Article | PubMed | ISI | ChemPort |
- Banerji MA et al. (1995) Prolongation of near normoglycemic remission in black NIDDM subjects with chronic low-dose sulfonylurea treatment. Diabetes 44: 466–470 | Article | PubMed | ISI | ChemPort |
- O’Brien PE et al. (2006) Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program: a randomized trial. Ann Intern Med 144: 625–633 | PubMed | ISI |
- Angrisani L et al. (2004) Italian Group for Lap-Band System: results of multicenter study on patients with BMI < or = 35 kg/m2. Obes Surg 14: 415–418 | Article | PubMed | ISI | ChemPort |
- Buchwald H et al. (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292: 1724–1737 | Article | PubMed | ISI | ChemPort |
- Miller K et al. (2007) Vertical banded gastroplasty versus adjustable gastric banding: prospective long-term follow-up study. Surg Obes Relat Dis 3: 84–90 | Article | PubMed |
- Favretti F et al. (2002) Laparoscopic banding: selection and technique in 830 patients. Obes Surg 12: 385–390 | Article | PubMed | ISI | ChemPort |
- O’Brien PE and Dixon JB (2003) Laparoscopic adjustable gastric banding in the treatment of morbid obesity. Arch Surg 138: 376–382 | PubMed | ISI |
- DeMaria EJ and Jamal MK (2005) Laparoscopic adjustable gastric banding: evolving clinical experience. Surg Clin North Am 85: 773–787 | Article | PubMed | ISI |
- Parikh MS et al. (2005) US experience with 749 laparoscopic adjustable gastric bands: intermediate outcomes. Surg Endosc 19: 1631–1635 | Article | PubMed | ISI | ChemPort |
- Sjöström L et al. (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351: 2683–2693 | Article | PubMed | ISI |
- Sjöström L (2006) Soft and hard endpoints over 5–18 years in the intervention trial Swedish obese subjects. Obes Rev 17 (Suppl 2): 27
- Flum DR and Dellinger EP (2004) Impact of gastric bypass operation on survival: a population-based analysis. J Am Coll Surg 199: 543–551 | Article | PubMed | ISI |
- MacDonald KG et al. (1997) The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus. J Gastrointest Surg 1: 213–220 | Article | PubMed |
- Dixon J (2006) Survival advantage with bariatric surgery: Report from the 10thInternational Congress on Obesity. Surg Obes Relat Dis 2: 585–586 | Article | PubMed |
- Mason EE et al. (1991) Impact of vertical banded gastroplasty on mortality from obesity [abstract]. Obes Surg 1: 115 | Article |
- Christou NV et al. (2004) Surgery decreases long-term mortality, morbidity and health care use in morbidly obese patients. Ann Surg 240: 416–423 | Article | PubMed | ISI |
- Sugerman HJ and Kral JG (2005) Evidence-based medicine reports on obesity surgery: a critique. Int J Obes 29: 735–745 | Article | ISI | ChemPort |
- Sugerman HJ (2002) Gastric bypass surgery for severe obesity. Semin Laparosc Surg 9: 79–85 | Article | PubMed |
- Scopinaro N et al. (2005) Specific effects of biliopancreatic diversion on the major components of metabolic syndrome. Diabetes Care 28: 2406–2411 | Article | PubMed | ISI |
- Kral JG (2004) Preventing and treating obesity in girls and young women to curb the epidemic. Obes Res 12: 1539–1546 | PubMed | ISI |
- Kral JG et al. (2006) Large maternal weight loss from obesity surgery prevents transmission of obesity to children followed 2–18 years. Pediatrics 118: e1644–e1649 | Article | PubMed | ISI |
- Fernandez AZ et al. (2004) Multivariate analysis of risk factors for death following gastric bypass for treatment of morbid obesity. Ann Surg 239: 698–702 | Article | PubMed | ISI |
- Flum DR and Dellinger EP (2004) Impact of gastric bypass operation on survival: a population based study. J Am Coll Surg 199: 543–551 | Article | PubMed | ISI |
- Flum DR et al. (2005) Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures. JAMA 294: 1903–1908 | Article | PubMed | ISI | ChemPort |
- Nguyen NT et al. (2004) The relationship between hospital volume and outcome in bariatric surgery at academic medical centers. Ann Surg 240: 586–594 | PubMed | ISI |
- Chapman AE et al. (2004) Laparoscopic adjustable gastric banding in the treatment of obesity: a systematic literature review. Surgery 135: 326–351 | Article | PubMed | ISI |
- Podnos YD et al. (2003) Complications after laparoscopic gastric bypass: a review of 3464 cases. Arch Surg 138: 957–961 | Article | PubMed | ISI |
- Behrns KE et al. (1994) Prospective evaluation of gastric acid secretion and cobalamin absorption following gastric bypass for clinically severe obesity. Dig Dis Sci 39: 315–320 | Article | PubMed | ISI | ChemPort |
- Chapin BL et al. (1996) Secondary hyperparathyroidism following biliopancreatic diversion. Arch Surg 131: 1048–1052 | PubMed | ISI | ChemPort |
- Johnson JM et al. (2005) Effects of gastric bypass procedures on bone mineral density, calcium, parathyroid hormone, and vitamin D. J Gastrointest Surg 9: 1106–1110 | Article | PubMed | ISI |
- Livingston EH (2005) Complications of bariatric surgery. Surg Clin North Am85: 853–868 | Article | PubMed | ISI |
- Mognol P et al. (2004) Laparoscopic conversion of laparoscopic gastric banding to Roux-en-Y gastric bypass: a review of 70 patients. Obes Surg 14: 1349–1353 | Article | PubMed | ISI |
- DeMaria EJ et al. (2005) The optimal surgical management of the super-obese patient: the debate. Surg Innov 12: 107–121 | PubMed |
- Regan JP et al. (2003) Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg 13: 861–864 | Article | PubMed | ISI | ChemPort |
- Lane DA et al. (1985) A risk-benefit analysis of gastric obesity surgery. InRecent Advances in Obesity Research: IV, 260–266 (Eds Hirsch J et al.) London, UK: John Libbey
- Martin LF et al. (1998) Cost-benefit analysis for the treatment of severe obesity. World J Surg 22: 1008–1017 | Article | PubMed | ISI | ChemPort |
- Kral JG (2006) Swedish obese subjects study—best available data to support antiobesity surgery? Surg Obes Relat Dis 2: 561–564 | Article | PubMed |
- Nguyen NT et al. (2003) Factors associated with operative outcomes in laparoscopic gastric bypass. J Am Coll Surg 197: 548–555 | Article | PubMed | ISI |
- Kral JG et al. (1992) Assessment of quality of life before and after surgery for severe obesity. Am J Clin Nutr 55: 611s–614s | PubMed | ChemPort |
- Brolin RE (1992) Critical analysis of results: weight loss and quality of data.Am J Clin Nutr 55: 577s–581s | PubMed | ChemPort |
- Herpertz S (2004) Do psychosocial variables predict weight loss or mental health after obesity surgery? A systematic review. Obes Res 12: 1554–1569 | PubMed | ISI | ChemPort |
- Livingston EH et al. (2002) Male gender is a predictor of morbidity and age a predictor of mortality for patients undergoing gastric bypass surgery. Ann Surg 236: 576–582 | Article | PubMed | ISI |
- Knol JA (1994) Management of the problem patient after bariatric surgery.Gastroenterol Clin North Am 23: 345–369 | PubMed | ISI | ChemPort |
- Kral JG (2006) ABC of obesity management: Part III—Surgery. BMJ 333: 900–903 | Article | PubMed |
- Sugerman HJ et al. (1989) Weight loss with vertical banded gastroplasty and Roux-Y gastric bypass for morbid obesity with selective versus random assignment. Am J Surg 157: 93–102 | Article | PubMed | ISI | ChemPort |
- Parikh M et al. (2006) Comparison of outcomes after laparoscopic adjustable gastric banding in African-Americans and whites. Surg Obes Relat Dis 2: 607–610 | Article | PubMed |
- Pekkarinen T (1994) Long-term results of gastroplasty for morbid obesity: binge-eating as a predictor of outcome. Obes Res 4: 248–255
- Mitchell JE et al. (2001) Long-term follow-up of patients’ status after gastric bypass. Obes Surg 11: 464–468 | Article | PubMed | ISI | ChemPort |
- Busetto L et al. (2002) Outcome predictors in morbidly obese recipients of an adjustable gastric band. Obes Surg 12: 83–92 | Article | PubMed | ISI |
- Powers PS et al. (1999) Eating pathology before and after bariatric surgery: a prospective study. Int J Eating Disord 25: 293–300 | ISI | ChemPort |
- Adami GF et al. (1996) Binge eating in obesity. Int J Obes Relat Metab Disord20: 793–794 | PubMed | ChemPort |
- Branson R et al. (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutation. N Engl J Med 348: 1096–1103 | Article | PubMed | ISI | ChemPort |
- Tao YX (2005) Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol 239: 1–14 | Article | PubMed | ISI | ChemPort |
- Potoczna N et al. (2004) Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity. J Gastrointestinal Surg 8: 971–982 | ISI |
- MacLean LD et al. (2000) Late outcome of isolated gastric bypass. Ann Surg231: 524–528 | Article | PubMed | ISI | ChemPort |
- Hsu LK et al. (1998) Nonsurgical factors that influence the outcome of bariatric surgery. A review. Psychosom Med 60: 338–346 | PubMed | ISI | ChemPort |
- Suadicani P et al. (1997) Weight changes and risk of ischemic heart disease for middle aged and elderly men. J Cardiovasc Risk 4: 25–32 | PubMed | ChemPort |
- Tang S and Kral JG (1988) Malabsorptive procedures after failed gastroplasty [abstract]. Int J Obes 12: 608
- Kral JG (1992) Overview of surgical techniques for treating obesity. Am J Clin Nutr 55: 552S–555S | PubMed | ChemPort |
- Mason EE (2003) The future of obesity surgery. IBSR Newsletter 18: 9–10
- Biertho L et al. (2005) Management of failed adjustable gastric banding.Surgery 137: 33–41 | Article | PubMed | ISI |