Effects of ingesting Lactobacillus- andBifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori

Effects of ingesting Lactobacillus- andBifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori1,2,3

Kuan-Yuan Wang, Shui-Nin Li, Chiang-Shin Liu, Daw-Shyong Perng, Yu-Chung Su, Deng-Chyang Wu, Chang-Ming Jan, Chun-Huang Lai, Tsu-Nai Wang and Wen-Ming Wang
From the Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan, Republic of China (K-YW and C-HL); the Department of Biology (S-NL) and the School of Public Health (T-NW), Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; and the Department of Pathology (C-SL) and the Department of Internal Medicine (D-SP, Y-CS, D-CW, C-MJ, and W-MW), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China

Background: Evidence suggests that ingesting lactic acid bacteria exerts a suppressive effect on Helicobacter pylori infection in both animals and humans. Supplementing withLactobacillus– and Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication of H. pylori in humans.

Objective: We administered AB-yogurt to subjects with asymptomatic H. pylori to test whether the yogurt could inhibit H. pylori growth.

Design: The in vitro inhibition of H. pylori growth was determined by inoculatingLactobacillus acidophilus La5 or Bifidobacterium lactis Bb12 on plates that were inoculated with H. pylori. Assessment of the viability of H. pylori was performed by the mixed culture method with La5 or Bb12. In an intervention study, 59 adult volunteers infected with H. pylori were given AB-yogurt (107 colony-forming units of both La5 and Bb12/mL) twice daily after a meal for 6 wk. Eleven subjects positive for H. pylori infection were treated with milk placebo as control subjects. H. pylori bacterial loads were determined with use of the 13C-urea breath test, which was performed before and 4 and 8 wk after the start of AB-yogurt supplementation.

Results: Bb12 exerted an in vitro inhibitory effect against H. pylori, whereas La5 did not show an effect. Administration of AB-yogurt decreased the urease activity of H. pyloriafter 6 wk of therapy (P < 0.0001).

Conclusion: Regular intake of yogurt containing Bb12 and La5 effectively suppressed H. pylori infection in humans.

Key Words: Probiotics • Bifidobacterium lactis Bb12 • Lactobacillus acidophilus La5 • urea breath test • yogurt • Helicobacter pylori

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