Effectiveness and safety of laparoscopic Roux-en-Y Gastric bypass in treating type 2diabetes mellitus in non-morbidly obese patients

[Effectiveness and safety of laparoscopic Roux-en-Y Gastric bypass in treating type 2diabetes mellitus in non-morbidly obese patients].


Bariatric & Metabolic International Surgery Center, International Minimally Invasive Surgery Training Center, E Da Hospital, Taiwan. dr.ckhuang@hotmail.com



To evaluate the effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGB) for achieving type 2 diabetes mellitus (T2DM) remission in patients with body mass index (BMI) in the range of 25-35 kg/m(2).


Twenty-two non-morbidly obese (BMI: 25-35 kg/m(2)) patients with T2DM underwent LRYGB. The changes of BMI, fasting plasma glucose (FPG), and glycosylated hemoglobin (HbA1c) levels were recorded, and the prognostic factors were analyzed.


All these 22 patients successfully underwent LRYGB and were followed up for twelve months. Two patients (9.1%) developed complications: one patient had an early hemorrhage at the gastrojejunostomy site, and the other had frequent loose stools that required revision surgery. At 12 months, 14 patients (63.6%) showed T2DM remission, 6 (27.3%) showed glycemic control, and 2(9.1%) showed improvement. Compared with the latter two groups, patients in the T2DM remission group had significantly higher BMI (P=0.001), younger age (P=0.002), and shorter duration of diabetes (P=0.001) before operation.


LYRGB can efficiently and safely treat T2DM in non-morbidly obese patients. Early intervention in these patients may yield better outcomes.


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